Assay Detail
Binding
CHEMBL5374124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BCR-ABL1 T315I mutant using Tyr2 peptide as substrate incubated for 1 hrs by FRET based Z-LYTE assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Expanding the Chemical Space: New Approach to Cell-Permeable Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.90 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 8.38 |
| CHEMBL4208229 | ASCIMINIB | 4.0 | 1 | 8.19 |
| CHEMBL5423801 | — | — | 1 | 8.14 |
| CHEMBL5435926 | — | — | 1 | 7.62 |
| CHEMBL5414962 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171837 | PONATINIB | EC50 | = | 4.18 | nM | 8.38 |
| CHEMBL4208229 | ASCIMINIB | EC50 | = | 6.45 | nM | 8.19 |
| CHEMBL5423801 | — | EC50 | = | 7.23 | nM | 8.14 |
| CHEMBL5435926 | — | EC50 | = | 23.8 | nM | 7.62 |
| CHEMBL5414962 | — | EC50 | = | 64.03 | nM | 7.19 |