Assay Detail
Functional
CHEMBL5374154
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Antiproliferative activity against RAS initiative G12D cells assessed as reduction in cell viability after 5 days of treatment by Cell-Titer Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RAS initiative G12D cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.84 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5408369 | — | — | 1 | 8.24 |
| CHEMBL4858364 | MRTX-1133 | 1.0 | 1 | 7.79 |
| CHEMBL5428238 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5408369 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4858364 | MRTX-1133 | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL5428238 | — | IC50 | = | 33.4 | nM | 7.48 |