Assay Detail
Functional
CHEMBL5374162
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Antiproliferative activity against human GP2d cells assessed as reduction in cell viability measured after 5 days by Cell-Titer Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GP2d |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.60 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428238 | — | — | 1 | 9.70 |
| CHEMBL5408369 | — | — | 1 | 9.70 |
| CHEMBL4858364 | MRTX-1133 | 1.0 | 1 | 9.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428238 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5408369 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4858364 | MRTX-1133 | IC50 | = | 0.4 | nM | 9.40 |