Assay Detail
Functional
CHEMBL5374221
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Antiviral activity against enterovirus D68 US/MO/14-18947 infected in human RD cells assessed as reduction in virus induced cytopathic effect by neutral red staining based CPE assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | enterovirus D68 |
| Cell Type | RD |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 6.18 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399008 | — | — | 1 | 6.96 |
| CHEMBL5435851 | — | — | 1 | 6.89 |
| CHEMBL5394438 | — | — | 1 | 6.85 |
| CHEMBL5438854 | — | — | 1 | 6.80 |
| CHEMBL5402821 | — | — | 1 | 6.80 |
| CHEMBL5397126 | — | — | 1 | 6.80 |
| CHEMBL5394625 | — | — | 1 | 6.75 |
| CHEMBL5424968 | — | — | 1 | 6.72 |
| CHEMBL5398293 | — | — | 1 | 6.64 |
| CHEMBL5420564 | — | — | 1 | 6.62 |
| CHEMBL5407374 | — | — | 1 | 6.60 |
| CHEMBL5434016 | — | — | 1 | 6.58 |
| CHEMBL5410248 | — | — | 1 | 6.55 |
| CHEMBL5397211 | — | — | 1 | 6.46 |
| CHEMBL5425956 | — | — | 1 | 6.42 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.35 |
| CHEMBL5406422 | — | — | 1 | 6.24 |
| CHEMBL5404698 | — | — | 1 | 6.16 |
| CHEMBL5419538 | — | — | 1 | 6.16 |
| CHEMBL5434982 | — | — | 1 | 6.12 |
| CHEMBL5420910 | — | — | 1 | 6.11 |
| CHEMBL5414707 | — | — | 1 | 6.08 |
| CHEMBL5422388 | — | — | 1 | 6.00 |
| CHEMBL5424560 | — | — | 1 | 5.89 |
| CHEMBL5437159 | — | — | 1 | 5.76 |
| CHEMBL5420845 | — | — | 1 | 5.73 |
| CHEMBL5408695 | — | — | 1 | 5.71 |
| CHEMBL5416816 | — | — | 1 | 5.64 |
| CHEMBL5438810 | — | — | 1 | 5.54 |
| CHEMBL5404439 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399008 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5435851 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5394438 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5438854 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5402821 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5397126 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5394625 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5424968 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5398293 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5420564 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5407374 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5434016 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5410248 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5397211 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5425956 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5406422 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5404698 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5419538 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5434982 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5420910 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5414707 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5422388 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5424560 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5437159 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5420845 | — | EC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL5408695 | — | EC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5416816 | — | EC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL5438810 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5404439 | — | EC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL5396722 | — | EC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL5419806 | — | EC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL5418897 | — | EC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL5407025 | — | EC50 | = | 25890.0 | nM | 4.59 |
| CHEMBL5416244 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL5404347 | — | EC50 | > | 290.0 | nM | - |
| CHEMBL5424831 | — | EC50 | > | 1840.0 | nM | - |
| CHEMBL5435904 | — | EC50 | > | 30000.0 | nM | - |