Assay Detail
Binding
CHEMBL5374223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Enterovirus D68 US/KY/14-18953 2A protease expressed in Escherichia coli BL21(DE3) assessed as inhibition constant using Dabcyl-KIRIVNT/GPGEGGE-Edans as substrate incubated for 2 hrs by FRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | enterovirus D68 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.82 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5435851 | — | — | 1 | 7.29 |
| CHEMBL5397126 | — | — | 1 | 7.23 |
| CHEMBL5399008 | — | — | 1 | 6.95 |
| CHEMBL5424560 | — | — | 1 | 6.56 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5435851 | — | Ki | = | 51.4 | nM | 7.29 |
| CHEMBL5397126 | — | Ki | = | 58.6 | nM | 7.23 |
| CHEMBL5399008 | — | Ki | = | 111.8 | nM | 6.95 |
| CHEMBL5424560 | — | Ki | = | 275.8 | nM | 6.56 |
| CHEMBL231813 | TELAPREVIR | Ki | = | 823.9 | nM | 6.08 |