Assay Detail
Binding
CHEMBL5374265
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Inhibition of NOX-2 dependent superoxide generation in PMA-stimulated African green monkey COS7phox cells incubated for 1 hr by WST-1 based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Chlorocebus aethiops |
| Cell Type | COS7phox cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.24 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426199 | — | — | 1 | 5.70 |
| CHEMBL5419067 | — | — | 1 | 5.52 |
| CHEMBL5410142 | — | — | 1 | 5.40 |
| CHEMBL5400222 | — | — | 1 | 5.28 |
| CHEMBL5412241 | — | — | 1 | 5.22 |
| CHEMBL5398246 | — | — | 1 | 5.21 |
| CHEMBL5429601 | — | — | 1 | 5.14 |
| CHEMBL5422613 | — | — | 1 | 5.07 |
| CHEMBL5427803 | — | — | 1 | 4.96 |
| CHEMBL5410678 | — | — | 1 | 4.92 |
| CHEMBL5408659 | — | — | 1 | - |
| CHEMBL5411352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426199 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5419067 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5410142 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5400222 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5412241 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5398246 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5429601 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5422613 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5427803 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5410678 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5408659 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL5411352 | — | IC50 | > | 500000.0 | nM | - |