Assay Detail

CHEMBL5374602

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Cytotoxicity against human MDA-MB-231 cells assessed as inhbition of cell growth measured after 48 hrs by CCK-8 method

ChEMBL ↗

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Target

MDA-MB-231 (CHEMBL400) ↗

Open DB target context

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MDA-MB-231 (CHEMBL400) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MDA-MB-231

CHEMBL400

Anchored from Assay target.

Protein identity MDA-MB-231

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MDA-MB-231
Confidence	1 — Organism
Curated By	Autocuration

Target

MDA-MB-231 (CHEMBL400) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Rational Design of Bioorthogonally Activatable PROTAC for Tumor-Targeted Protein Degradation.

Bi T, Liang P, Zhou Y, Wang H, Huang R, Sun Q, Shen H, Yang S, Ren W, Liu Z.
J Med Chem (2023) 66 : 14843 -14852
PubMed 37871321 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.42	6.65

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5440773	—	—	1	6.65
CHEMBL5394958	—	—	1	6.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5440773	—	IC50	=	225.4	nM	6.65
CHEMBL5394958	—	IC50	=	652.2	nM	6.19