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Assay Detail

CHEMBL5374608

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against 12 hrs BODIPY-TZ treated human MCF7 cells assessed as inhbition of cell growth measured after 48 hrs by CCK-8 method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Rational Design of Bioorthogonally Activatable PROTAC for Tumor-Targeted Protein Degradation.
Bi T, Liang P, Zhou Y, Wang H, Huang R, Sun Q, Shen H, Yang S, Ren W, Liu Z.
J Med Chem (2023) 66 : 14843 -14852
PubMed 37871321 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.58 6.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5394958 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5394958 IC50 = 263.6 nM 6.58