Assay Detail
Binding
CHEMBL5374993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC6 using RHKKAc (379 to 382 residues) as substrate
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.11 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356769 | TUBACIN | — | 1 | 8.40 |
| CHEMBL5422921 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356769 | TUBACIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5422921 | — | IC50 | = | 15.0 | nM | 7.82 |