Assay Detail
Binding
CHEMBL5375276
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as acid mediated amyloid-like fibril formation by measuring turbidity incubated for 1 week at 310K in presence of sodium acetate by absorbance based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.28 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.68 |
| CHEMBL597744 | TRIACETYLRESVERATROL | — | 1 | 5.66 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.57 |
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 5.51 |
| CHEMBL110370 | — | — | 1 | 5.50 |
| CHEMBL498917 | — | — | 1 | 5.47 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 5.46 |
| CHEMBL43065 | OXYRESVERATROL | — | 1 | 5.35 |
| CHEMBL69863 | PICEATANNOL | — | 1 | 5.27 |
| CHEMBL44509 | (E)-3,4,3',5'-TETRAMETHOXYSTILBENE | — | 1 | 4.31 |
| CHEMBL5426941 | — | — | 1 | 4.27 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL898 | DIFLUNISAL | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL597744 | TRIACETYLRESVERATROL | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL165 | RESVERATROL | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL2103837 | TAFAMIDIS | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL110370 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL498917 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL83527 | PTEROSTILBENE | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL43065 | OXYRESVERATROL | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL69863 | PICEATANNOL | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL44509 | (E)-3,4,3',5'-TETRAMETHOXYSTILBENE | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL5426941 | — | Ki | = | 54000.0 | nM | 4.27 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | Ki | - | — | - |