Assay Detail
Binding
CHEMBL5375277
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Binding affinity to recombinant N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as quenching of intrinsic tryptophan fluorescence by measuring apparent dissociation constant incubated for 60 mins by fluorescence based analysis
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.59 | 6.14 |
| Kd(app) | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110370 | — | — | 1 | 6.14 |
| CHEMBL498917 | — | — | 1 | 5.92 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.85 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 5.72 |
| CHEMBL69863 | PICEATANNOL | — | 1 | 5.68 |
| CHEMBL43065 | OXYRESVERATROL | — | 1 | 5.62 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | — | 1 | 5.39 |
| CHEMBL44509 | (E)-3,4,3',5'-TETRAMETHOXYSTILBENE | — | 1 | 5.16 |
| CHEMBL5426941 | — | — | 1 | 4.85 |
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | - |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | - |
| CHEMBL597744 | TRIACETYLRESVERATROL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110370 | — | Kd | = | 730.0 | nM | 6.14 |
| CHEMBL498917 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL165 | RESVERATROL | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL83527 | PTEROSTILBENE | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL69863 | PICEATANNOL | Kd | = | 2100.0 | nM | 5.68 |
| CHEMBL43065 | OXYRESVERATROL | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | Kd | = | 4100.0 | nM | 5.39 |
| CHEMBL44509 | (E)-3,4,3',5'-TETRAMETHOXYSTILBENE | Kd | = | 6900.0 | nM | 5.16 |
| CHEMBL5426941 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL2103837 | TAFAMIDIS | Kd(app) | - | — | - | |
| CHEMBL898 | DIFLUNISAL | Kd(app) | - | — | - | |
| CHEMBL597744 | TRIACETYLRESVERATROL | Kd(app) | - | — | - |