Assay Detail
Binding
CHEMBL5375281
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Binding affinity to N-terminal hexa-histidine tagged TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as dissociation constant at 60 uM by ITC assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 5.75 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 6.58 |
| CHEMBL110370 | — | — | 1 | 5.92 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.85 |
| CHEMBL43065 | OXYRESVERATROL | — | 1 | 5.85 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 5.82 |
| CHEMBL69863 | PICEATANNOL | — | 1 | 5.82 |
| CHEMBL498917 | — | — | 1 | 5.62 |
| CHEMBL83527 | PTEROSTILBENE | 2.0 | 1 | 5.34 |
| CHEMBL5426941 | — | — | 1 | 4.96 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | — | 1 | - |
| CHEMBL597744 | TRIACETYLRESVERATROL | — | 1 | - |
| CHEMBL44509 | (E)-3,4,3',5'-TETRAMETHOXYSTILBENE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL110370 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL898 | DIFLUNISAL | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL43065 | OXYRESVERATROL | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL165 | RESVERATROL | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL69863 | PICEATANNOL | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL498917 | — | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL83527 | PTEROSTILBENE | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL5426941 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL296411 | TRISMETHOXYRESVERATROL | Kd | - | — | - | |
| CHEMBL597744 | TRIACETYLRESVERATROL | Kd | - | — | - | |
| CHEMBL44509 | (E)-3,4,3',5'-TETRAMETHOXYSTILBENE | Kd | - | — | - |