Assay Detail
Functional
CHEMBL5375763
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SUP-B15 cells assessed as cell growth inhibition incubated for 72 hrs by Cell Titer-Glo Luminescent assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SUP-B15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Atypical <i>N</i>-Alkyl to <i>N</i>-Noralkoxy Switch in a Dual cSRC/BCR-ABL1 Kinase Inhibitor Improves Drug Efflux and hERG Affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.54 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.68 |
| CHEMBL5435819 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5435819 | — | IC50 | = | 410.0 | nM | 6.39 |