Assay Detail

CHEMBL5376474

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Toxicity

Cytotoxicity against human Z138 cells

ChEMBL ↗

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Target

Z-138 (CHEMBL4483276) ↗

Open DB target context

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Primary target Z-138

CHEMBL4483276

Anchored from Assay target.

Protein identity Z-138

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Toxicity
Organism	Homo sapiens
Cell Type	Z-138
Confidence	1 — Organism
Curated By	Autocuration

Target

Z-138 (CHEMBL4483276) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

The evolution of small molecule enzyme activators.

Dow LF, Case AM, Paustian MP, Pinkerton BR, Simeon P, Trippier PC.
RSC Med Chem (2023) 14 : 2206 -2230
PubMed 37974956 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.00	6.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4297310	DORDAVIPRONE	3.0	1	6.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4297310	DORDAVIPRONE	IC50	=	1000.0	nM	6.00