Assay Detail
Binding
CHEMBL5376501
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Agonist activity at MRGPRX4 83S expressed in human HEK293 cells co- expressing Gq assessed as change in intracellular calcium level by calcium mobilization assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Beware the Receptor Variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.48 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398225 | — | — | 1 | 7.95 |
| CHEMBL5429208 | — | — | 1 | 4.88 |
| CHEMBL406393 | DEOXYCHOLIC ACID | 4.0 | 1 | 4.77 |
| CHEMBL1551 | URSODIOL | 4.0 | 1 | 4.32 |
| CHEMBL412272 | TAURODEOXYCHOLIC ACID | 2.0 | 1 | - |
| CHEMBL783 | NATEGLINIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398225 | — | EC50 | = | 11.2 | nM | 7.95 |
| CHEMBL5429208 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL406393 | DEOXYCHOLIC ACID | EC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL1551 | URSODIOL | EC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL412272 | TAURODEOXYCHOLIC ACID | EC50 | > | 10000.0 | nM | - |
| CHEMBL783 | NATEGLINIDE | EC50 | > | 10000.0 | nM | - |