Assay Detail
Functional
CHEMBL5376803
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Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.90 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.89 |
| CHEMBL5412066 | — | — | 1 | 6.10 |
| CHEMBL4577077 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5412066 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4577077 | — | EC50 | = | 1300.0 | nM | 5.89 |