Assay Detail
Binding
CHEMBL5377229
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Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase kinase 2 (CHEMBL5284) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.06 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422255 | — | — | 1 | 6.54 |
| CHEMBL5394508 | — | — | 1 | 6.29 |
| CHEMBL5416036 | — | — | 1 | 6.28 |
| CHEMBL5412289 | — | — | 1 | 6.21 |
| CHEMBL5395520 | — | — | 1 | 5.70 |
| CHEMBL5434028 | — | — | 1 | 5.35 |
| CHEMBL5430196 | — | — | 1 | - |
| CHEMBL5440885 | — | — | 1 | - |
| CHEMBL5424004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422255 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5394508 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5416036 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5412289 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5395520 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5434028 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5430196 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5440885 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5424004 | — | EC50 | > | 10000.0 | nM | - |