Assay Detail
Binding
CHEMBL5377320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bim (unknown origin)- N-terminal 6His-tagged human recombinant HSP70 NBD (1 to 383 residues) expressed in Escherichia coli BL21 (DE3) protein protein interaction assessed as suppression of BimBH3-stimulated HSP70 ATPase activity
24
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploiting the "Hot-Spots" of Hsp70<b>-</b>Bim Protein<b>-</b>Protein Interaction to Optimize the 1-Oxo-1<i>H</i>-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70<b>-</b>Bim Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 23 | - | - |
| IC50 | 1 | 4.80 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397919 | — | — | 2 | 4.80 |
| CHEMBL5440571 | — | — | 1 | - |
| CHEMBL4872862 | — | — | 1 | - |
| CHEMBL5429550 | — | — | 1 | - |
| CHEMBL5420298 | — | — | 1 | - |
| CHEMBL5434117 | — | — | 1 | - |
| CHEMBL4552126 | — | — | 1 | - |
| CHEMBL5420274 | — | — | 1 | - |
| CHEMBL5422777 | — | — | 1 | - |
| CHEMBL5415430 | — | — | 1 | - |
| CHEMBL5394274 | — | — | 1 | - |
| CHEMBL5399955 | — | — | 1 | - |
| CHEMBL5419880 | — | — | 1 | - |
| CHEMBL5408762 | — | — | 1 | - |
| CHEMBL5439121 | — | — | 1 | - |
| CHEMBL5429113 | — | — | 1 | - |
| CHEMBL5428322 | — | — | 1 | - |
| CHEMBL5403612 | — | — | 1 | - |
| CHEMBL5434308 | — | — | 1 | - |
| CHEMBL5429681 | — | — | 1 | - |
| CHEMBL5410012 | — | — | 1 | - |
| CHEMBL5414624 | — | — | 1 | - |
| CHEMBL5438116 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397919 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL5419880 | — | Inhibition | - | % | - | |
| CHEMBL4872862 | — | Inhibition | - | % | - | |
| CHEMBL5429550 | — | Inhibition | - | % | - | |
| CHEMBL5420298 | — | Inhibition | - | % | - | |
| CHEMBL5434117 | — | Inhibition | - | % | - | |
| CHEMBL4552126 | — | Inhibition | - | % | - | |
| CHEMBL5420274 | — | Inhibition | - | % | - | |
| CHEMBL5422777 | — | Inhibition | - | % | - | |
| CHEMBL5415430 | — | Inhibition | - | % | - | |
| CHEMBL5394274 | — | Inhibition | - | % | - | |
| CHEMBL5399955 | — | Inhibition | - | % | - | |
| CHEMBL5438116 | — | Inhibition | - | % | - | |
| CHEMBL5408762 | — | Inhibition | - | % | - | |
| CHEMBL5439121 | — | Inhibition | - | % | - | |
| CHEMBL5429113 | — | Inhibition | - | % | - | |
| CHEMBL5428322 | — | Inhibition | - | % | - | |
| CHEMBL5403612 | — | Inhibition | - | % | - | |
| CHEMBL5434308 | — | Inhibition | - | % | - | |
| CHEMBL5429681 | — | Inhibition | - | % | - | |
| CHEMBL5397919 | — | Inhibition | - | % | - | |
| CHEMBL5410012 | — | Inhibition | - | % | - | |
| CHEMBL5414624 | — | Inhibition | - | % | - | |
| CHEMBL5440571 | — | Inhibition | - | % | - |