Assay Detail
Functional
CHEMBL5377329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human Imatinib-resistant K562-R3 cells incubated for 24 hrs by annexin V/PI staining based flow cytometry analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Imatinib-resistant K562-R3 cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Exploiting the "Hot-Spots" of Hsp70<b>-</b>Bim Protein<b>-</b>Protein Interaction to Optimize the 1-Oxo-1<i>H</i>-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70<b>-</b>Bim Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.92 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397919 | — | — | 1 | 6.47 |
| CHEMBL5434308 | — | — | 1 | 6.35 |
| CHEMBL5419880 | — | — | 1 | 5.77 |
| CHEMBL470334 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397919 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5434308 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5419880 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL470334 | — | EC50 | = | 8500.0 | nM | 5.07 |