Assay Detail
Binding
CHEMBL5377862
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant JAK1 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assay
40
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 8.09 | 10.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397297 | — | — | 1 | 10.36 |
| CHEMBL5398372 | — | — | 2 | 9.25 |
| CHEMBL5413283 | — | — | 1 | 9.24 |
| CHEMBL5423944 | — | — | 1 | 9.20 |
| CHEMBL5405043 | — | — | 2 | 9.10 |
| CHEMBL5408324 | — | — | 2 | 8.96 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 8.90 |
| CHEMBL5410919 | — | — | 1 | 8.73 |
| CHEMBL5393770 | — | — | 1 | 8.63 |
| CHEMBL5441087 | — | — | 1 | 8.61 |
| CHEMBL5427932 | — | — | 1 | 8.59 |
| CHEMBL5405140 | — | — | 1 | 8.57 |
| CHEMBL5435417 | — | — | 1 | 8.54 |
| CHEMBL5440017 | — | — | 1 | 8.53 |
| CHEMBL5439582 | — | — | 1 | 8.48 |
| CHEMBL5434116 | — | — | 1 | 8.30 |
| CHEMBL5430795 | — | — | 1 | 8.28 |
| CHEMBL5404261 | — | — | 1 | 8.25 |
| CHEMBL5423387 | — | — | 1 | 8.19 |
| CHEMBL5410927 | — | — | 1 | 8.04 |
| CHEMBL5413771 | — | — | 1 | 8.03 |
| CHEMBL5423894 | — | — | 1 | 7.99 |
| CHEMBL5420407 | — | — | 1 | 7.95 |
| CHEMBL5400756 | — | — | 1 | 7.93 |
| CHEMBL4742766 | — | — | 1 | 7.89 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 7.78 |
| CHEMBL5396523 | — | — | 1 | 7.78 |
| CHEMBL5396079 | — | — | 1 | 7.56 |
| CHEMBL5417546 | — | — | 1 | 7.47 |
| CHEMBL5430831 | — | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397297 | — | IC50 | = | 0.044 | nM | 10.36 |
| CHEMBL5398372 | — | IC50 | = | 0.563 | nM | 9.25 |
| CHEMBL5413283 | — | IC50 | = | 0.577 | nM | 9.24 |
| CHEMBL5423944 | — | IC50 | = | 0.637 | nM | 9.20 |
| CHEMBL5405043 | — | IC50 | = | 0.799 | nM | 9.10 |
| CHEMBL5408324 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL5410919 | — | IC50 | = | 1.86 | nM | 8.73 |
| CHEMBL5393770 | — | IC50 | = | 2.34 | nM | 8.63 |
| CHEMBL5441087 | — | IC50 | = | 2.46 | nM | 8.61 |
| CHEMBL5427932 | — | IC50 | = | 2.59 | nM | 8.59 |
| CHEMBL5405140 | — | IC50 | = | 2.691 | nM | 8.57 |
| CHEMBL5435417 | — | IC50 | = | 2.86 | nM | 8.54 |
| CHEMBL5440017 | — | IC50 | = | 2.934 | nM | 8.53 |
| CHEMBL5439582 | — | IC50 | = | 3.32 | nM | 8.48 |
| CHEMBL5434116 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5430795 | — | IC50 | = | 5.26 | nM | 8.28 |
| CHEMBL5404261 | — | IC50 | = | 5.68 | nM | 8.25 |
| CHEMBL5423387 | — | IC50 | = | 6.51 | nM | 8.19 |
| CHEMBL5410927 | — | IC50 | = | 9.23 | nM | 8.04 |
| CHEMBL5413771 | — | IC50 | = | 9.38 | nM | 8.03 |
| CHEMBL5423894 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL5420407 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL5400756 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL4742766 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL5396523 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5396079 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL5417546 | — | IC50 | = | 34.2 | nM | 7.47 |
| CHEMBL5430831 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL5440026 | — | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL5440077 | — | IC50 | = | 49.4 | nM | 7.31 |
| CHEMBL5405043 | — | IC50 | = | 56.1 | nM | 7.25 |
| CHEMBL5408389 | — | IC50 | = | 57.6 | nM | 7.24 |
| CHEMBL5408324 | — | IC50 | = | 76.8 | nM | 7.12 |
| CHEMBL5440699 | — | IC50 | = | 82.2 | nM | 7.08 |
| CHEMBL5397572 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5402123 | — | IC50 | = | 97.5 | nM | 7.01 |
| CHEMBL5398372 | — | IC50 | = | 112.4 | nM | 6.95 |
| CHEMBL5435251 | — | IC50 | = | 285.6 | nM | 6.54 |