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Assay Detail

CHEMBL5378333

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to His6-tagged KIND2 (unknown origin) expressed in Escherichia coli BL21(DE3) by MST assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fermitin family homolog 2 (CHEMBL5465266)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction.
Kitel R, Surmiak E, Borggräfe J, Kalinowska-Tluscik J, Golik P, Czub M, Uzar W, Musielak B, Madej M, Popowicz GM, Dubin G, Holak TA.
J Med Chem (2023) 66 : 15715 -15727
PubMed 38039505 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 4.09 4.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99254 1 4.12
CHEMBL5394576 1 4.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99254 Kd = 75000.0 nM 4.12
CHEMBL5394576 Kd = 87700.0 nM 4.06