Assay Detail
Functional
CHEMBL5378356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell migration in human U-937 cells assessed as inhibition of 7alpha,25-OHC induced chemotaxis pretreated for 0.5 hrs followed by 7alpha,25-OHC addition and measured after 3 hrs by Transwell migration assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.26 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5394700 | — | — | 1 | 8.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5394700 | — | IC50 | = | 5.5 | nM | 8.26 |