Assay Detail
Functional
CHEMBL5378357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell migration in human Th17 cells assessed as inhibition of 7alpha,25-OHC induced chemotaxis pretreated for 0.5 hrs followed by 7alpha,25-OHC addition and measured after 3 hrs by Transwell migration assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Th17 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.42 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5394700 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5394700 | — | IC50 | = | 3.8 | nM | 8.42 |