Assay Detail
Binding
CHEMBL5378455
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Inhibition of human recombinant GSK3 assessed as incorporation of 33Pi using [gamma-33P]-ATP measured after 60 mins by microplate scintillation counting based radiometric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.38 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1802358 | — | — | 1 | 5.81 |
| CHEMBL5426285 | 5-(6-BENZOTHIAZOLYLMETHYLENE)-3,5-DIHYDRO-2-(((1S)-1-(METHOXYMETHYL)-3-METHYLBUTYL)AMINO)-4H-IMIDAZOL-4-ONE, (5Z)- | 1.0 | 1 | 5.70 |
| CHEMBL5412105 | — | — | 1 | 5.63 |
| CHEMBL5429359 | — | — | 1 | 5.37 |
| CHEMBL5085086 | — | — | 1 | 5.35 |
| CHEMBL5403642 | — | — | 1 | 5.33 |
| CHEMBL5433334 | — | — | 1 | 5.10 |
| CHEMBL5408047 | — | — | 1 | 5.09 |
| CHEMBL5406672 | — | — | 1 | 5.05 |
| CHEMBL485053 | LEUCETTAMINE B | — | 1 | - |
| CHEMBL5432405 | — | — | 1 | - |
| CHEMBL5430240 | — | — | 1 | - |
| CHEMBL5424188 | — | — | 1 | - |
| CHEMBL5426979 | — | — | 1 | - |
| CHEMBL5413380 | — | — | 1 | - |
| CHEMBL5404093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1802358 | — | IC50 | = | 1544.0 | nM | 5.81 |
| CHEMBL5426285 | 5-(6-BENZOTHIAZOLYLMETHYLENE)-3,5-DIHYDRO-2-(((1S)-1-(METHOXYMETHYL)-3-METHYLBUTYL)AMINO)-4H-IMIDAZOL-4-ONE, (5Z)- | IC50 | = | 2008.5 | nM | 5.70 |
| CHEMBL5412105 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL5429359 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL5085086 | — | IC50 | = | 4481.0 | nM | 5.35 |
| CHEMBL5403642 | — | IC50 | = | 4694.0 | nM | 5.33 |
| CHEMBL5433334 | — | IC50 | = | 7867.0 | nM | 5.10 |
| CHEMBL5408047 | — | IC50 | = | 8165.0 | nM | 5.09 |
| CHEMBL5406672 | — | IC50 | = | 8988.0 | nM | 5.05 |
| CHEMBL485053 | LEUCETTAMINE B | IC50 | > | 10000.0 | nM | - |
| CHEMBL5432405 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5430240 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5424188 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5426979 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5413380 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5404093 | — | IC50 | > | 10000.0 | nM | - |