Assay Detail
Functional
CHEMBL5378748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human U2OS cells harboring p53 assessed inhibition of cell growth incubated for 4 days by celltiter-glo assay
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.41 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5425989 | — | — | 2 | 7.97 |
| CHEMBL5408617 | — | — | 1 | 7.97 |
| CHEMBL5438520 | — | — | 1 | 6.96 |
| CHEMBL5413376 | — | — | 1 | 6.81 |
| CHEMBL5395046 | — | — | 1 | 6.59 |
| CHEMBL5431530 | — | — | 1 | 6.52 |
| CHEMBL5405147 | — | — | 1 | 6.42 |
| CHEMBL5402394 | — | — | 1 | 6.24 |
| CHEMBL5406959 | — | — | 1 | 6.20 |
| CHEMBL5405110 | — | — | 1 | 6.20 |
| CHEMBL5436528 | — | — | 1 | 6.19 |
| CHEMBL5403772 | — | — | 1 | 6.12 |
| CHEMBL5398827 | — | — | 1 | 6.01 |
| CHEMBL5400878 | — | — | 1 | 5.90 |
| CHEMBL5421232 | — | — | 1 | 5.80 |
| CHEMBL5423147 | — | — | 1 | 5.73 |
| CHEMBL5394717 | — | — | 1 | 5.55 |
| CHEMBL5403609 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5425989 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL5408617 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL5425989 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5438520 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL5413376 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5395046 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL5431530 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL5405147 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL5402394 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL5406959 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL5405110 | — | IC50 | = | 634.0 | nM | 6.20 |
| CHEMBL5436528 | — | IC50 | = | 647.0 | nM | 6.19 |
| CHEMBL5403772 | — | IC50 | = | 752.0 | nM | 6.12 |
| CHEMBL5398827 | — | IC50 | = | 985.0 | nM | 6.01 |
| CHEMBL5400878 | — | IC50 | = | 1271.0 | nM | 5.90 |
| CHEMBL5421232 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL5423147 | — | IC50 | = | 1845.0 | nM | 5.73 |
| CHEMBL5394717 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL5403609 | — | IC50 | = | 3410.0 | nM | 5.47 |