Assay Detail
Functional
CHEMBL5378798
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Growth inhibition of human HeLa cells harboring p53 incubated for 4 days by CCK-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.34 | 7.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438520 | — | — | 1 | 7.93 |
| CHEMBL5425989 | — | — | 1 | 7.91 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 7.55 |
| CHEMBL5397752 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438520 | — | IC50 | = | 11.63 | nM | 7.93 |
| CHEMBL5425989 | — | IC50 | = | 12.24 | nM | 7.91 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 28.23 | nM | 7.55 |
| CHEMBL5397752 | — | IC50 | = | 1132.0 | nM | 5.95 |