Assay Detail
Binding
CHEMBL5378938
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Agonist activity at full length human RXR alpha expressed in HEK293T cells measured after 16 hrs by Dual-glo luciferase assay
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Fusion of Natural and Synthetic Ligand Features Boosts RXR Agonist Potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.77 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404648 | — | — | 2 | 9.15 |
| CHEMBL5412777 | — | — | 1 | 7.80 |
| CHEMBL5407623 | — | — | 1 | 7.66 |
| CHEMBL5436895 | — | — | 1 | 7.46 |
| CHEMBL5399947 | — | — | 1 | 6.03 |
| CHEMBL5395851 | — | — | 1 | 5.92 |
| CHEMBL5394779 | — | — | 1 | 5.52 |
| CHEMBL5398853 | — | — | 1 | 4.98 |
| CHEMBL5417665 | — | — | 1 | 4.89 |
| CHEMBL5423123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404648 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5404648 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5412777 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5407623 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5436895 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5399947 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5395851 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5394779 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5398853 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL5417665 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5423123 | — | EC50 | > | 10000.0 | nM | - |