Assay Detail

CHEMBL5379045

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Functional

Cytotoxicity against p53 null human U-937 cells harboring p53 V272M mutant incubated for 48 hrs by CCK-8 assay

ChEMBL ↗

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Target

U-937 (CHEMBL612794) ↗

Open DB target context

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U-937 (CHEMBL612794) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target U-937

CHEMBL612794

Anchored from Assay target.

Protein identity U-937

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	U-937
Confidence	1 — Organism
Curated By	Autocuration

Target

U-937 (CHEMBL612794) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

AcGlcAs: A Novel P53-Targeting Arsenical with Potent Cellular Uptake and Cancer Cell Selectivity.

Liang Y, An Q, Song H, Tang Y, Xiao S, Wu J, Yan N, Yu B, Cao X, Lu M.
J Med Chem (2023) 66 : 16579 -16596
PubMed 38069817 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.31	6.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5431740	—	—	1	6.64
CHEMBL5483015	ARSENIC TRIOXIDE	4.0	1	5.97

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5431740	—	IC50	=	230.0	nM	6.64
CHEMBL5483015	ARSENIC TRIOXIDE	IC50	=	1070.0	nM	5.97