Assay Detail
Functional
CHEMBL5379463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small Molecule Inhibitors Targeting the "Undruggable" Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.17 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589013 | — | — | 1 | 6.80 |
| CHEMBL4634108 | — | — | 1 | 5.68 |
| CHEMBL4633379 | — | — | 1 | 5.46 |
| CHEMBL4633484 | — | — | 1 | 5.46 |
| CHEMBL5187860 | — | — | 1 | 5.37 |
| CHEMBL4635753 | — | — | 1 | 5.32 |
| CHEMBL4640789 | — | — | 1 | 5.32 |
| CHEMBL4641626 | — | — | 1 | 4.74 |
| CHEMBL4645530 | — | — | 1 | 4.71 |
| CHEMBL4637348 | — | — | 1 | 4.70 |
| CHEMBL4643757 | — | — | 1 | 4.68 |
| CHEMBL5420699 | — | — | 1 | 4.61 |
| CHEMBL4645485 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589013 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4634108 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4633379 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4633484 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5187860 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4635753 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4640789 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4641626 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4645530 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL4637348 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4643757 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL5420699 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL4645485 | — | IC50 | = | 49800.0 | nM | 4.30 |