Assay Detail
Functional
CHEMBL5379465
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Cytotoxicity against human LNCaP C4-2 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP C4-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small Molecule Inhibitors Targeting the "Undruggable" Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.32 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589013 | — | — | 1 | 6.77 |
| CHEMBL5187860 | — | — | 1 | 5.72 |
| CHEMBL4635753 | — | — | 1 | 5.51 |
| CHEMBL4645530 | — | — | 1 | 4.90 |
| CHEMBL4643757 | — | — | 1 | 4.84 |
| CHEMBL5420699 | — | — | 1 | 4.75 |
| CHEMBL4641626 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589013 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5187860 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4635753 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4645530 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4643757 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL5420699 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL4641626 | — | IC50 | = | 18600.0 | nM | 4.73 |