Assay Detail
Binding
CHEMBL5380230
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Inhibition of human recombinant P-gp ATPase activity in isolated membranes incubated in presence of verapamil by firefly luciferase based luminescence analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Consensus screening for a challenging target: the quest for P-glycoprotein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.37 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426932 | — | — | 1 | 5.89 |
| CHEMBL5399482 | — | — | 1 | 5.62 |
| CHEMBL5409299 | — | — | 1 | 5.50 |
| CHEMBL5437506 | — | — | 1 | 5.48 |
| CHEMBL5402786 | — | — | 1 | 5.32 |
| CHEMBL5394140 | — | — | 1 | 5.30 |
| CHEMBL5405630 | — | — | 1 | 5.10 |
| CHEMBL487805 | SCUTELLARIN | — | 1 | 4.71 |
| CHEMBL5403462 | — | — | 1 | - |
| CHEMBL5420251 | — | — | 1 | - |
| CHEMBL5417022 | — | — | 1 | - |
| CHEMBL5400953 | — | — | 1 | - |
| CHEMBL5401400 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426932 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5399482 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5409299 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL5437506 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL5402786 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5394140 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL5405630 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL487805 | SCUTELLARIN | IC50 | = | 19710.0 | nM | 4.71 |
| CHEMBL5403462 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5420251 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5417022 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5400953 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5401400 | — | IC50 | > | 50000.0 | nM | - |