Assay Detail
Binding
CHEMBL5380301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin) incubated for 1 hr by ELISA analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.97 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908360 | EVEROLIMUS | 4.0 | 1 | 6.28 |
| CHEMBL5437417 | — | — | 1 | 6.08 |
| CHEMBL5432408 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908360 | EVEROLIMUS | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5437417 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5432408 | — | IC50 | = | 2850.0 | nM | 5.54 |