Assay Detail
Binding
CHEMBL5380327
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Inhibition of human VEGFR-2 kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate preincubated for 30 mins followed by compound addition incubated for 1 hrs by ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Role of heterocycles in inhibition of VEGFR-2 - a recent update (2019-2022).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.38 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5437292 | — | — | 1 | 5.44 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5437292 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 4850.0 | nM | 5.31 |