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Assay Detail

CHEMBL5381283

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Binding
Binding affinity to human P300 assessed as dissociation constant by isothermal titration calorimetry assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone acetyltransferase p300 (CHEMBL3784)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent Advances on Small-Molecule Bromodomain-Containing Histone Acetyltransferase Inhibitors.
Liu M, Zhang K, Li Q, Pang H, Pan Z, Huang X, Wang L, Wu F, He G.
J Med Chem (2023) 66 : 1678 -1699
PubMed 36695774 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 7.46 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3622373 1 7.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3622373 Kd = 35.0 nM 7.46