Assay Detail
Binding
CHEMBL5381439
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 8-((4-chlorophenyl)amino)naphthalene-1-sulfonic acid binding to CDK2 (unknown origin) measured after 2 hrs by fluorescence based analysis
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 5.32 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397283 | — | — | 1 | 7.06 |
| CHEMBL5439308 | — | — | 1 | 7.00 |
| CHEMBL258805 | SU-9516 | 1.0 | 1 | 6.96 |
| CHEMBL5432928 | — | — | 1 | 6.80 |
| CHEMBL5406341 | — | — | 1 | 6.60 |
| CHEMBL5423185 | — | — | 1 | 6.52 |
| CHEMBL5421048 | — | — | 1 | 6.43 |
| CHEMBL5439522 | — | — | 1 | 6.36 |
| CHEMBL5434594 | — | — | 1 | 6.04 |
| CHEMBL5413829 | — | — | 1 | 6.03 |
| CHEMBL5436881 | — | — | 1 | 5.96 |
| CHEMBL346119 | THEAFLAVIN | — | 1 | 5.80 |
| CHEMBL1257080 | — | — | 1 | 5.70 |
| CHEMBL5423683 | — | — | 1 | 5.55 |
| CHEMBL23293 | SALIRASIB | 2.0 | 1 | 5.51 |
| CHEMBL271673 | — | — | 1 | 5.46 |
| CHEMBL5427324 | — | — | 1 | 5.41 |
| CHEMBL5435410 | — | — | 1 | 5.40 |
| CHEMBL5430461 | — | — | 1 | 5.34 |
| CHEMBL5428330 | — | — | 1 | 5.34 |
| CHEMBL5410597 | — | — | 1 | 5.30 |
| CHEMBL5413135 | — | — | 1 | 5.25 |
| CHEMBL5421310 | — | — | 1 | 5.24 |
| CHEMBL5401897 | — | — | 1 | 5.21 |
| CHEMBL256057 | ACID BLUE 25 | — | 1 | 5.19 |
| CHEMBL5404588 | — | — | 1 | 5.18 |
| CHEMBL3964783 | — | — | 1 | 5.17 |
| CHEMBL307145 | PYROGALLOL | -1.0 | 1 | 5.17 |
| CHEMBL5400738 | — | — | 1 | 5.10 |
| CHEMBL366861 | FUMARPROTOCETRARIC ACID | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397283 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5439308 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL258805 | SU-9516 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5432928 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5406341 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5423185 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5421048 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5439522 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5434594 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5413829 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5436881 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL346119 | THEAFLAVIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1257080 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5423683 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL23293 | SALIRASIB | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL271673 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL5427324 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5435410 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5430461 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5428330 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5410597 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5413135 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5421310 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5401897 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL256057 | ACID BLUE 25 | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5404588 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL307145 | PYROGALLOL | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3964783 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5400738 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL366861 | FUMARPROTOCETRARIC ACID | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5427192 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5401470 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5419968 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL12131 | CLOSANTEL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5404611 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5412165 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5394608 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5413620 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1332616 | ERYTHROSINE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5394312 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5440790 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5428382 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5427167 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5412113 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1256759 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL5432063 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5407688 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5407777 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL5427047 | — | IC50 | = | 45000.0 | nM | 4.35 |