Assay Detail
Binding
CHEMBL5381508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 6-His tagged XPNPEP1 (unknown origin) expressed in Escherichia coli Rosetta DE3 cells using H-Lys(abz)-Pro-Pro-pNA as substrate incubated for 60 mins by fluorescence based analysis
47
Total Activities
47
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 4.64 | 5.77 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397935 | — | — | 1 | 5.77 |
| CHEMBL5402862 | — | — | 1 | 5.70 |
| CHEMBL5438224 | — | — | 1 | 5.66 |
| CHEMBL5433668 | — | — | 1 | 5.54 |
| CHEMBL5400780 | — | — | 1 | 5.47 |
| CHEMBL5393876 | — | — | 1 | 5.16 |
| CHEMBL5435178 | — | — | 1 | 5.09 |
| CHEMBL5403523 | — | — | 1 | 5.00 |
| CHEMBL5430934 | — | — | 1 | 4.96 |
| CHEMBL5412099 | — | — | 1 | 4.92 |
| CHEMBL5436435 | — | — | 1 | 4.85 |
| CHEMBL5419938 | — | — | 1 | 4.85 |
| CHEMBL311875 | — | — | 1 | 4.75 |
| CHEMBL5401781 | — | — | 1 | 4.64 |
| CHEMBL5409645 | — | — | 1 | 4.48 |
| CHEMBL5421582 | — | — | 1 | 4.42 |
| CHEMBL5399924 | — | — | 1 | 4.39 |
| CHEMBL5410658 | — | — | 1 | 4.37 |
| CHEMBL5421036 | — | — | 1 | 4.33 |
| CHEMBL5419034 | — | — | 1 | 4.32 |
| CHEMBL5419166 | — | — | 1 | 4.28 |
| CHEMBL5415840 | — | — | 1 | 4.24 |
| CHEMBL5438777 | — | — | 1 | 4.24 |
| CHEMBL5404330 | — | — | 1 | 4.19 |
| CHEMBL5403929 | — | — | 1 | 4.18 |
| CHEMBL5432938 | — | — | 1 | 4.17 |
| CHEMBL5398054 | — | — | 1 | 4.16 |
| CHEMBL5407130 | — | — | 1 | 4.13 |
| CHEMBL5419889 | — | — | 1 | 4.08 |
| CHEMBL5429139 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397935 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5402862 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5438224 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5433668 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5400780 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5393876 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5435178 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL5403523 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5430934 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5412099 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5436435 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5419938 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL311875 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5401781 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5409645 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL5421582 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5399924 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL5410658 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL5421036 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL5419034 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL5419166 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL5415840 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL5438777 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL5404330 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL5403929 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL5432938 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL5398054 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL5407130 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL5419889 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL5429139 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL5427035 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL5415378 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL5403681 | — | IC50 | = | 241000.0 | nM | - |
| CHEMBL5396150 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL5394915 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL5435351 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL5406619 | — | IC50 | = | 203000.0 | nM | - |
| CHEMBL5403940 | — | IC50 | = | 324000.0 | nM | - |
| CHEMBL5433606 | — | IC50 | = | 154000.0 | nM | - |
| CHEMBL5412812 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL457092 | BESTATIN METHYL ESTER | IC50 | = | 298000.0 | nM | - |
| CHEMBL5437413 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL5433567 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL5396773 | — | IC50 | = | 303000.0 | nM | - |
| CHEMBL5424113 | — | Inhibition | - | % | - | |
| CHEMBL5408940 | — | Inhibition | - | % | - | |
| CHEMBL5426465 | — | Inhibition | - | % | - |