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Assay Detail

CHEMBL5381509

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by celltiter-glo assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.
Chen Q, Wang A, Covelli DJ, Bhattacharjee A, Wang Q, Orth-He EL, Rao SD, Huang HC, Ball DP, Hsiao JC, Bachovchin DA.
J Med Chem (2023) 66 : 2589 -2607
PubMed 36724486 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 5.34 6.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5410658 1 6.57
CHEMBL5438224 1 6.37
CHEMBL5399924 1 6.35
CHEMBL5401781 1 6.22
CHEMBL5397935 1 6.19
CHEMBL5419034 1 6.18
CHEMBL5400780 1 6.08
CHEMBL5436435 1 6.00
CHEMBL5402862 1 5.89
CHEMBL5437413 1 5.66
CHEMBL5393876 1 5.52
CHEMBL457092 BESTATIN METHYL ESTER 1 5.41
CHEMBL5415378 1 5.27
CHEMBL5433606 1 5.25
CHEMBL5419938 1 5.14
CHEMBL5430934 1 5.09
CHEMBL5403940 1 5.09
CHEMBL5404330 1 5.00
CHEMBL5429139 1 4.96
CHEMBL5398054 1 4.85
CHEMBL5406619 1 4.82
CHEMBL5433567 1 4.82
CHEMBL5419166 1 4.77
CHEMBL5415840 1 4.72
CHEMBL5435178 1 4.46
CHEMBL5394915 1 4.34
CHEMBL5421036 1 4.22
CHEMBL5407130 1 4.21
CHEMBL311875 1 -
CHEMBL5433668 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5410658 IC50 = 270.0 nM 6.57
CHEMBL5438224 IC50 = 430.0 nM 6.37
CHEMBL5399924 IC50 = 450.0 nM 6.35
CHEMBL5401781 IC50 = 600.0 nM 6.22
CHEMBL5397935 IC50 = 650.0 nM 6.19
CHEMBL5419034 IC50 = 660.0 nM 6.18
CHEMBL5400780 IC50 = 840.0 nM 6.08
CHEMBL5436435 IC50 = 1000.0 nM 6.00
CHEMBL5402862 IC50 = 1300.0 nM 5.89
CHEMBL5437413 IC50 = 2200.0 nM 5.66
CHEMBL5393876 IC50 = 3000.0 nM 5.52
CHEMBL457092 BESTATIN METHYL ESTER IC50 = 3900.0 nM 5.41
CHEMBL5415378 IC50 = 5400.0 nM 5.27
CHEMBL5433606 IC50 = 5600.0 nM 5.25
CHEMBL5419938 IC50 = 7300.0 nM 5.14
CHEMBL5430934 IC50 = 8200.0 nM 5.09
CHEMBL5403940 IC50 = 8100.0 nM 5.09
CHEMBL5404330 IC50 = 10000.0 nM 5.00
CHEMBL5429139 IC50 = 11000.0 nM 4.96
CHEMBL5398054 IC50 = 14000.0 nM 4.85
CHEMBL5406619 IC50 = 15000.0 nM 4.82
CHEMBL5433567 IC50 = 15000.0 nM 4.82
CHEMBL5419166 IC50 = 17000.0 nM 4.77
CHEMBL5415840 IC50 = 19000.0 nM 4.72
CHEMBL5435178 IC50 = 35000.0 nM 4.46
CHEMBL5394915 IC50 = 46000.0 nM 4.34
CHEMBL5421036 IC50 = 60000.0 nM 4.22
CHEMBL5407130 IC50 = 61000.0 nM 4.21
CHEMBL5412812 IC50 > 100000.0 nM -
CHEMBL5396150 IC50 > 100000.0 nM -
CHEMBL5403929 IC50 > 100000.0 nM -
CHEMBL5421582 IC50 > 100000.0 nM -
CHEMBL5412099 IC50 > 100000.0 nM -
CHEMBL5396773 IC50 > 100000.0 nM -
CHEMBL5432938 IC50 > 100000.0 nM -
CHEMBL5403523 IC50 > 100000.0 nM -
CHEMBL5409645 IC50 > 100000.0 nM -
CHEMBL5419889 IC50 > 100000.0 nM -
CHEMBL5403681 IC50 > 100000.0 nM -
CHEMBL5438777 IC50 > 100000.0 nM -
CHEMBL5435351 IC50 > 100000.0 nM -
CHEMBL5427035 IC50 > 100000.0 nM -
CHEMBL5433668 IC50 > 100000.0 nM -
CHEMBL311875 IC50 > 20000.0 nM -