Assay Detail
Toxicity
CHEMBL5381577
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Inhibition of human ERG tail current by plate-based planar patch clamp method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.27 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5400637 | — | — | 1 | 5.82 |
| CHEMBL5398790 | — | — | 1 | 5.44 |
| CHEMBL5423660 | — | — | 1 | 5.42 |
| CHEMBL5424734 | — | — | 1 | 5.39 |
| CHEMBL5407684 | — | — | 1 | 5.35 |
| CHEMBL5432698 | — | — | 1 | 5.34 |
| CHEMBL5421791 | — | — | 1 | 5.29 |
| CHEMBL5413311 | — | — | 1 | 5.28 |
| CHEMBL5399407 | — | — | 1 | 5.27 |
| CHEMBL5427353 | — | — | 1 | 5.24 |
| CHEMBL5424508 | — | — | 1 | 5.17 |
| CHEMBL5427839 | — | — | 1 | 5.16 |
| CHEMBL5424726 | — | — | 1 | 5.00 |
| CHEMBL5394023 | — | — | 1 | 4.92 |
| CHEMBL4868243 | — | — | 1 | 4.89 |
| CHEMBL5436976 | — | — | 1 | - |
| CHEMBL5432663 | — | — | 1 | - |
| CHEMBL5404810 | — | — | 1 | - |
| CHEMBL5430566 | — | — | 1 | - |
| CHEMBL5440088 | — | — | 1 | - |
| CHEMBL5426983 | — | — | 1 | - |
| CHEMBL5426160 | — | — | 1 | - |
| CHEMBL5420450 | — | — | 1 | - |
| CHEMBL5408358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5400637 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5398790 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5423660 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5424734 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5407684 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5432698 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5421791 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5413311 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5399407 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5427353 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5424508 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5427839 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5424726 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5394023 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4868243 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5436976 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5432663 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5404810 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5430566 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5440088 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5426983 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5426160 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5420450 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL5408358 | — | IC50 | > | 40000.0 | nM | - |