Assay Detail
Functional
CHEMBL5381809
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Reversal of vinorelbine resistance in human NCI/ADR-RES cells assessed as reduction in cell viability incubated for 72 hrs in presence of vinorelbine (Rvb = 6125.7+/-3267.7 nM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.56 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399206 | — | — | 1 | 6.94 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.54 |
| CHEMBL5437817 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399206 | — | IC50 | = | 115.7 | nM | 6.94 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 288.6 | nM | 6.54 |
| CHEMBL5437817 | — | IC50 | = | 619.3 | nM | 6.21 |