Assay Detail
Functional
CHEMBL5381810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of vinorelbine resistance in human OVCAR-8 cells assessed as reduction in cell viability incubated for 72 hrs in presence of vinorelbine (Rvb = 16.2+/-4.7 nM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.19 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399206 | — | — | 1 | 8.34 |
| CHEMBL5437817 | — | — | 1 | 8.17 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399206 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5437817 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 8.5 | nM | 8.07 |