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Assay Detail

CHEMBL5382176

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CK2 (unknown origin)
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Casein kinase 2 (CHEMBL3832943)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Strategies of Targeting CK2 in Drug Discovery: Challenges, Opportunities, and Emerging Prospects.
Chen Y, Wang Y, Wang J, Zhou Z, Cao S, Zhang J.
J Med Chem (2023) 66 : 2257 -2281
PubMed 36745746 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.84 8.64
Ki 1 6.75 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1682283 1 8.64
CHEMBL1682297 1 8.04
CHEMBL5430283 1 7.50
CHEMBL5437737 1 7.30
CHEMBL5409262 1 7.20
CHEMBL1229512 1 7.00
CHEMBL3353413 1 6.77
CHEMBL5430563 1 6.75
CHEMBL1229652 1 6.70
CHEMBL4070389 1 6.43
CHEMBL92361 1 6.41
CHEMBL32749 FERULATE -1.0 1 6.08
CHEMBL289277 EMODIN 1 5.70
CHEMBL4439686 1 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1682283 IC50 = 2.3 nM 8.64
CHEMBL1682297 IC50 = 9.1 nM 8.04
CHEMBL5430283 IC50 = 32.0 nM 7.50
CHEMBL5437737 IC50 = 50.0 nM 7.30
CHEMBL5409262 IC50 = 63.0 nM 7.20
CHEMBL1229512 IC50 = 100.0 nM 7.00
CHEMBL3353413 IC50 = 170.0 nM 6.77
CHEMBL5430563 Ki = 180.0 nM 6.75
CHEMBL1229652 IC50 = 200.0 nM 6.70
CHEMBL4070389 IC50 = 370.0 nM 6.43
CHEMBL92361 IC50 = 390.0 nM 6.41
CHEMBL32749 FERULATE IC50 = 840.0 nM 6.08
CHEMBL289277 EMODIN IC50 = 2000.0 nM 5.70
CHEMBL4439686 IC50 = 7000.0 nM 5.16