Assay Detail

CHEMBL5382178

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Binding

Inhibition of CLK2 (unknown origin)

ChEMBL ↗

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Target

Dual specificity protein kinase CLK2 (CHEMBL4225) ↗

Open DB target context

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Dual specificity protein kinase CLK2 (CHEMBL4225) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Dual specificity protein kinase CLK2

CHEMBL4225

Anchored from Assay target.

Protein identity Dual specificity protein kinase CLK2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Dual specificity protein kinase CLK2 (CHEMBL4225) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Strategies of Targeting CK2 in Drug Discovery: Challenges, Opportunities, and Emerging Prospects.

Chen Y, Wang Y, Wang J, Zhou Z, Cao S, Zhang J.
J Med Chem (2023) 66 : 2257 -2281
PubMed 36745746 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.26	9.26

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1230165	SILMITASERTIB	2.0	1	9.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1230165	SILMITASERTIB	IC50	=	0.55	nM	9.26