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Assay Detail

CHEMBL5382958

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human HeLa cells incubated for 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing.
Elzahhar PA, Nematalla HA, Al-Koussa H, Abrahamian C, El-Yazbi AF, Bodgi L, Bou-Gharios J, Azzi J, Al Choboq J, Labib HF, Kheir WA, Abu-Serie MM, Elrewiny MA, El-Yazbi AF, Belal ASF.
J Med Chem (2023) 66 : 4565 -4587
PubMed 36921275 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.95 7.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5423492 1 7.23
CHEMBL5398658 1 7.21
CHEMBL5397378 1 7.11
CHEMBL5439883 1 7.09
CHEMBL5426678 1 7.08
CHEMBL5418979 1 7.06
CHEMBL5433427 1 7.01
CHEMBL5416201 1 6.97
CHEMBL5402742 1 6.95
CHEMBL5395379 1 6.94
CHEMBL5417587 1 6.92
CHEMBL5414232 1 6.89
CHEMBL572 NITROFURANTOIN 4.0 1 6.78
CHEMBL5409734 1 6.74
CHEMBL185 FLUOROURACIL 4.0 1 6.70
CHEMBL5402001 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5423492 IC50 = 59.0 nM 7.23
CHEMBL5398658 IC50 = 62.0 nM 7.21
CHEMBL5397378 IC50 = 78.0 nM 7.11
CHEMBL5439883 IC50 = 81.0 nM 7.09
CHEMBL5426678 IC50 = 84.0 nM 7.08
CHEMBL5418979 IC50 = 87.0 nM 7.06
CHEMBL5433427 IC50 = 97.0 nM 7.01
CHEMBL5416201 IC50 = 108.0 nM 6.97
CHEMBL5402742 IC50 = 113.0 nM 6.95
CHEMBL5395379 IC50 = 115.0 nM 6.94
CHEMBL5417587 IC50 = 121.0 nM 6.92
CHEMBL5414232 IC50 = 129.0 nM 6.89
CHEMBL572 NITROFURANTOIN IC50 = 166.0 nM 6.78
CHEMBL5409734 IC50 = 183.0 nM 6.74
CHEMBL185 FLUOROURACIL IC50 = 199.0 nM 6.70
CHEMBL5402001 IC50 = 265.0 nM 6.58