Assay Detail
Binding
CHEMBL5383384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC6 (unknown origin) assessed as release of fluorogenic AMC preincubated for 15 mins followed by addition of trypsin and substrate measured after 60 mins Spectra max microplate reader analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.16 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415232 | — | — | 1 | 8.57 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.75 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | - |
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | - |
| CHEMBL5431071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415232 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | > | 10000.0 | nM | - |
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | > | 10000.0 | nM | - |
| CHEMBL5431071 | — | IC50 | > | 10000.0 | nM | - |