Assay Detail
Functional
CHEMBL5383398
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Antiproliferative activity against human K562 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.32 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415232 | — | — | 1 | 6.82 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 6.49 |
| CHEMBL5431071 | — | — | 1 | 6.46 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.08 |
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415232 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL5431071 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 828.0 | nM | 6.08 |
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | = | 1775.0 | nM | 5.75 |