Assay Detail
Binding
CHEMBL5383502
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Inhibition of ROCK2 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Application and Study of ROCK Inhibitors in Pulmonary Fibrosis: Recent Developments and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.41 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397091 | — | — | 1 | 9.70 |
| CHEMBL5435792 | — | — | 1 | 8.84 |
| CHEMBL5424408 | — | — | 1 | 8.70 |
| CHEMBL5437972 | — | — | 1 | 7.85 |
| CHEMBL2005186 | BELUMOSUDIL | 4.0 | 1 | 6.98 |
| CHEMBL5407512 | — | — | 1 | - |
| CHEMBL5411884 | — | — | 1 | - |
| CHEMBL5427097 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397091 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5435792 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL5424408 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5437972 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2005186 | BELUMOSUDIL | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL5407512 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL5411884 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL5427097 | — | IC50 | < | 10.0 | nM | - |