Assay Detail
Binding
CHEMBL5384067
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Agonist activity at alpha4beta1 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of fibronectin-induced cell adhesion pre-incubated for 30 mins followed by 30 mins incubation in fibronectin coated wells by fluorescence plate reader assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat E6.1 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and Pharmacological Characterization of α<sub>4</sub>β<sub>1</sub> Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.90 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4589062 | — | — | 1 | 7.81 |
| CHEMBL5419935 | — | — | 1 | 7.39 |
| CHEMBL5410616 | — | — | 1 | 7.30 |
| CHEMBL5417237 | — | — | 1 | 7.25 |
| CHEMBL5408335 | — | — | 1 | 6.81 |
| CHEMBL5397743 | — | — | 1 | 5.97 |
| CHEMBL5437666 | — | — | 1 | 5.76 |
| CHEMBL4586928 | — | — | 1 | - |
| CHEMBL5416838 | — | — | 1 | - |
| CHEMBL5430513 | — | — | 1 | - |
| CHEMBL5420916 | — | — | 1 | - |
| CHEMBL5410871 | — | — | 1 | - |
| CHEMBL5418990 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4589062 | — | EC50 | = | 15.6 | nM | 7.81 |
| CHEMBL5419935 | — | EC50 | = | 40.9 | nM | 7.39 |
| CHEMBL5410616 | — | EC50 | = | 50.5 | nM | 7.30 |
| CHEMBL5417237 | — | EC50 | = | 55.6 | nM | 7.25 |
| CHEMBL5408335 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL5397743 | — | EC50 | = | 1061.0 | nM | 5.97 |
| CHEMBL5437666 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL4586928 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5416838 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5430513 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5420916 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5410871 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5418990 | — | EC50 | > | 5000.0 | nM | - |