Assay Detail
Binding
CHEMBL5384071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha4beta7 integrin receptor in human RPMI-8866 cells assessed as inhibition of mucosal vascular add-ressin cell adhesion molecule 1-induced cell adhesion pre-incubated for 30 mins followed by 30 mins incubation in mucosal vascular add-ressin cell adhesion molecule 1 coated wells by fluorescence plate reader assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RPMI-8866 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and Pharmacological Characterization of α<sub>4</sub>β<sub>1</sub> Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.50 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410616 | — | — | 1 | 7.50 |
| CHEMBL5408335 | — | — | 1 | 7.49 |
| CHEMBL5417237 | — | — | 1 | - |
| CHEMBL88478 | — | — | 1 | - |
| CHEMBL5419935 | — | — | 1 | - |
| CHEMBL4586928 | — | — | 1 | - |
| CHEMBL4589062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410616 | — | EC50 | = | 31.8 | nM | 7.50 |
| CHEMBL5408335 | — | EC50 | = | 32.1 | nM | 7.49 |
| CHEMBL5417237 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL88478 | — | EC50 | - | — | - | |
| CHEMBL5419935 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4586928 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4589062 | — | EC50 | > | 5000.0 | nM | - |