Assay Detail
Binding
CHEMBL5384075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha1beta2 integrin receptor in human Jurkat E6.1 cells assessed as inhibition of ICAM-1-induced cell adhesion pre-incubated for 30 mins followed by 30 mins incubation in ICAM-1 coated wells by fluorescence plate reader assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat E6.1 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and Pharmacological Characterization of α<sub>4</sub>β<sub>1</sub> Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.01 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410616 | — | — | 1 | 7.01 |
| CHEMBL4586928 | — | — | 1 | - |
| CHEMBL4589062 | — | — | 1 | - |
| CHEMBL5417237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410616 | — | EC50 | = | 98.2 | nM | 7.01 |
| CHEMBL4586928 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4589062 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5417237 | — | EC50 | > | 5000.0 | nM | - |