Assay Detail
Binding
CHEMBL5384077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha5beta1 integrin receptor in human K562 cells assessed as inhibition of fibronectin-induced cell adhesion pre-incubated for 30 mins followed by 1 hr incubation in fibronectin coated wells by fluorescence plate reader assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and Pharmacological Characterization of α<sub>4</sub>β<sub>1</sub> Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.83 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4586928 | — | — | 1 | 8.01 |
| CHEMBL5417237 | — | — | 1 | 6.78 |
| CHEMBL5395825 | — | — | 1 | 5.71 |
| CHEMBL5408335 | — | — | 1 | - |
| CHEMBL88478 | — | — | 1 | - |
| CHEMBL4589062 | — | — | 1 | - |
| CHEMBL5410616 | — | — | 1 | - |
| CHEMBL5419935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4586928 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL5417237 | — | EC50 | = | 168.0 | nM | 6.78 |
| CHEMBL5395825 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL5408335 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL88478 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4589062 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5410616 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5419935 | — | EC50 | > | 5000.0 | nM | - |